Clare Atkins, Massey University, New Zealand Gail Louw, University of Brighton Reclaiming knowledge: A case for evidence based information systems. The information base, on which both information systems (IS) research and practice is founded, continues to grow rapidly, as does its accessibility. A major challenge facing the IS community is discovering how to extract knowledge, useful to, and usable by, all in the community, from this fragmented, disparate, often conflicting and sometimes unevaluated resource. This challenge is not unique to IS, and the concept of 'evidence-based' practice is already widely used by the healthcare community to address these same issues. Emerging as a considered response to the increasing need for efficient and effective use of resources, evidence-based healthcare relies heavily on the timely dissemination of 'best evidence' to a wide audience of health practitioners. A formal methodology for the critical appraisal and systematic review of primary research has been developed and, through the mechanism of the Cochrane Collaboration, has become an important means of synthesising and disseminating significant amounts of information to inform practitioners' and managers' decision-making. Here, we explore the application of the fundamental elements of evidence-based healthcare, particularly developing rigorours appraisal guidelines and the 'systematic review' of all available evidence, to IS. Further details are available from our web-site, http://fims-www.massey.ac.nz/~is/centre.html